Cytomegalovirus-associated biliary atresia

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Evolving biliary atresia with cytomegalovirus.

Multiple studies have been conducted to demonstrate the role of viruses in causing biliary atresia. Although cytomegalovirus (CMV) is known to cause intrahepatic bile duct destruction, its role in biliary atresia is not proven. We report two cases of CMV infection, initially presenting with intrahepatic cholestasis, who subsequently developed biliary atresia.

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The phenomenon of patent biliary tree at birth and subsequent development of biliary atresia later in the neonatal or infantile period has never been documented till date. In that sense, the authors have tried to report this phenomenon for the first time in the world literature. However, there are several caveats in this hypothesis proposed by the authors [1]. Firstly, the diagnosis of patent b...

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Biliary atresia and cytomegalovirus infection: a DNA study.

The cause of extrahepatic biliary atresia (EHBA) is undetermined in most instances, but an infectious agent is widely suspected. Cytomegalovirus (CMV) infection has been associated with intrahepatic bile duct destruction and paucity, raising the question of its role in EHBA. We identified 12 children in the past 5 years with biliary atresia and examined the bile duct biopsy. These showed acute/...

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ژورنال

عنوان ژورنال: Journal of Pediatric Surgery Case Reports

سال: 2018

ISSN: 2213-5766

DOI: 10.1016/j.epsc.2018.02.002